About 20% of the population has good endocannabinoid genetics. These people were born with a genetic mutation that increases the level of endocannabinoids and levels of anandamide (the so-called bliss molecule) naturally occurring in their system. As a whole, the endocannabinoid system is partially responsible for regulating sleep, appetite, mood, motor control, immune function, pleasure, pain, reproduction and fertility, memory and temperature regulation. When someone consumes cannabis, the cannabinoids, like THC and CBD, replace the naturally occurring endocannabinoids in your body. Thus, if you are among the lucky few that have this genetic mutation, you are most likely less inclined to feel the effects of CBD because your body already naturally produces a similar result.
Men vs. Women
Cannabidiol products affect males and females differently. Research shows that estrogen makes women more sensitive to cannabis. That time of the month? Washington State University found that women are impacted more by THC a day or two before ovulation, because of the peak in estrogen levels.
Biochemistry, the study of chemical substances and vital processes occurring in living organisms is yet another explanation as to why people react differently to CBD products. No two individuals have the exact biochemistry makeup, which affects the way substances metabolize throughout our system. The health of one’s endocannabinoid system plays a significant role in this. As previously mentioned, the human body naturally produces endocannabinoids. Things like diet, stress, and overall lifestyle influences endocannabinoid levels. When consuming cannabis products, you are increasing endocannabinoid levels. For individuals who have deprived levels, cannabis consumption will most likely produce a favorable experience, whereas someone with healthy endocannabinoid levels might not “feel” the effects of CBD or other marijuana products.